Imaging of plexiform neurofibromas in neurofibromatosis type 1

Eva Dombi, Nicholas Patronas, Brigitte Widemann

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter describes the radiographic appearance and distribution of plexiformneurofibromas (PNs) in NF1. Although PNs are histologically benign tumors, they are thesource of significant morbidity including disfigurement, pain, functional impairment andthey can undergo malignant transformation. Identifying targeted agents that slow thegrowth or decrease the size of PNs is an area of intense research. Volumetric MRIanalysis of PNs is helpful in detecting treatment response and progression in these largeand complex shaped tumors with greater sensitivity compared to 1-dimensional or 2-dimensional measurements.

Original languageEnglish (US)
Title of host publicationNeurofibromatosis Type 1
Subtitle of host publicationSymptoms, Treatment and Prognosis
PublisherNova Science Publishers, Inc.
Number of pages18
ISBN (Print)9781628081596
StatePublished - Dec 1 2013

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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