Imaging human connectomes at the macroscale

R. Cameron Craddock, Saad Jbabdi, Chao Gan Yan, Joshua T. Vogelstein, F. Xavier Castellanos, Adriana Di Martino, Clare Kelly, Keith Heberlein, Stan Colcombe, Michael P. Milham

Research output: Contribution to journalReview articlepeer-review

Abstract

At macroscopic scales, the human connectome comprises anatomically distinct brain areas, the structural pathways connecting them and their functional interactions. Annotation of phenotypic associations with variation in the connectome and cataloging of neurophenotypes promise to transform our understanding of the human brain. In this Review, we provide a survey of magnetic resonance imaging-based measurements of functional and structural connectivity. We highlight emerging areas of development and inquiry and emphasize the importance of integrating structural and functional perspectives on brain architecture.

Original languageEnglish (US)
Pages (from-to)524-539
Number of pages16
JournalNature Methods
Volume10
Issue number6
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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