Imaging findings in a fatal case of pandemic swine-origin influenza A (H1N1)

Daniel J. Mollura, Deborah S. Asnis, Robert S. Crupi, Rick Conetta, David S. Feigin, Mike Bray, Jeffery K. Taubenberger, David A. Bluemke

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


OBJECTIVE. Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) have been self-limited, fatal cases raise questions about virulence and radiology's role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection. CONCLUSION. Radiography showed peripheral lung opacities. CT revealed peripheral ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.

Original languageEnglish (US)
Pages (from-to)1500-1503
Number of pages4
JournalAmerican Journal of Roentgenology
Issue number6
StatePublished - Dec 2009
Externally publishedYes


  • Chest CT
  • Emergency medicine
  • H1N1
  • Infectious diseases
  • Multifocal ground-glass opacities
  • Swine-origin influenza A

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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