Illumination of mitotic orchestra during cell division: A polo view

Kai Yuan; Yuejia Huang; Xuebiao Yao

doi:10.1016/j.cellsig.2010.07.003

Illumination of mitotic orchestra during cell division: A polo view

Kai Yuan, Yuejia Huang, Xuebiao Yao

Research output: Contribution to journal › Review article › peer-review

Abstract

Protein kinase and phosphatase signaling cascade, coupled with other post-translational modifications, orchestrates temporal order of various events during cell division. Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis. The advancement in optical reporter engineering and the recent development of specific chemical probes enable us to visualize spatiotemporal gradient of kinase activity at nano-scale. One of such tools is FRET-based optic sensor that allows us to delineate the PLK1 activity in space and time. In this review, we address the inter-relationships between PLK1 and other protein kinases/phosphatases, as well as the crosstalk between PLK1 phosphorylation and ubiquitination during cell division. In particular, we discuss the molecular mechanisms and steps underlying PLK1 kinase priming, activation and turn-off during cell division.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Cellular Signalling
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.cellsig.2010.07.003
State	Published - Jan 2011
Externally published	Yes

Keywords

Crosstalk
Mitosis
Polo-like kinase 1
Protein kinase and phosphatase signaling cascade
Ubiquitination

ASJC Scopus subject areas

Cell Biology

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10.1016/j.cellsig.2010.07.003

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title = "Illumination of mitotic orchestra during cell division: A polo view",

abstract = "Protein kinase and phosphatase signaling cascade, coupled with other post-translational modifications, orchestrates temporal order of various events during cell division. Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis. The advancement in optical reporter engineering and the recent development of specific chemical probes enable us to visualize spatiotemporal gradient of kinase activity at nano-scale. One of such tools is FRET-based optic sensor that allows us to delineate the PLK1 activity in space and time. In this review, we address the inter-relationships between PLK1 and other protein kinases/phosphatases, as well as the crosstalk between PLK1 phosphorylation and ubiquitination during cell division. In particular, we discuss the molecular mechanisms and steps underlying PLK1 kinase priming, activation and turn-off during cell division.",

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T2 - A polo view

AU - Yuan, Kai

AU - Huang, Yuejia

AU - Yao, Xuebiao

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N2 - Protein kinase and phosphatase signaling cascade, coupled with other post-translational modifications, orchestrates temporal order of various events during cell division. Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis. The advancement in optical reporter engineering and the recent development of specific chemical probes enable us to visualize spatiotemporal gradient of kinase activity at nano-scale. One of such tools is FRET-based optic sensor that allows us to delineate the PLK1 activity in space and time. In this review, we address the inter-relationships between PLK1 and other protein kinases/phosphatases, as well as the crosstalk between PLK1 phosphorylation and ubiquitination during cell division. In particular, we discuss the molecular mechanisms and steps underlying PLK1 kinase priming, activation and turn-off during cell division.

AB - Protein kinase and phosphatase signaling cascade, coupled with other post-translational modifications, orchestrates temporal order of various events during cell division. Among the many mitotic kinases, Polo-like kinase 1 (PLK1) as a key regulator, participates in regulating mitosis from mitotic entry to cytokinesis. The advancement in optical reporter engineering and the recent development of specific chemical probes enable us to visualize spatiotemporal gradient of kinase activity at nano-scale. One of such tools is FRET-based optic sensor that allows us to delineate the PLK1 activity in space and time. In this review, we address the inter-relationships between PLK1 and other protein kinases/phosphatases, as well as the crosstalk between PLK1 phosphorylation and ubiquitination during cell division. In particular, we discuss the molecular mechanisms and steps underlying PLK1 kinase priming, activation and turn-off during cell division.

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KW - Polo-like kinase 1

KW - Protein kinase and phosphatase signaling cascade

KW - Ubiquitination

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Illumination of mitotic orchestra during cell division: A polo view

Abstract

Keywords

ASJC Scopus subject areas

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