TY - JOUR
T1 - Illness Intrusiveness in Adults with Sickle Cell Disease
T2 - The Role of Fatigue
AU - McGill, Lakeya S.
AU - Hughes, Abbey J.
AU - Carroll, C. Patrick
AU - Bediako, Shawn M.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - Chronic illness experiences often interfere with daily functioning (a concept known as illness intrusiveness) and health-related quality of life (HRQoL). However, less is known about the role of specific symptoms in predicting illness intrusiveness in sickle cell disease (SCD). This exploratory study examined associations between common SCD-related symptoms (i.e., pain, fatigue, depression, and anxiety), illness intrusiveness, and HRQoL among adults with SCD (n = 60). Illness intrusiveness significantly correlated with fatigue severity (r =.39, p =.002), depression severity (r =.45, p <.001), anxiety severity (r =.41, p =.001), physical HRQoL (r = − .53, p <.001), and mental HRQoL (r = − .44, p <.001). Multiple regression revealed a significant overall model, (R2 =.28, F(4, 55) = 5.21, p =.001), with fatigue, but not pain, depression, or anxiety, significantly predicting illness intrusiveness (β =.29, p =.036). Results suggest that fatigue may be a primary factor contributing to illness intrusiveness—a determinant of HRQoL—in individuals with SCD. Given the limited sample size, larger confirmatory studies are warranted.
AB - Chronic illness experiences often interfere with daily functioning (a concept known as illness intrusiveness) and health-related quality of life (HRQoL). However, less is known about the role of specific symptoms in predicting illness intrusiveness in sickle cell disease (SCD). This exploratory study examined associations between common SCD-related symptoms (i.e., pain, fatigue, depression, and anxiety), illness intrusiveness, and HRQoL among adults with SCD (n = 60). Illness intrusiveness significantly correlated with fatigue severity (r =.39, p =.002), depression severity (r =.45, p <.001), anxiety severity (r =.41, p =.001), physical HRQoL (r = − .53, p <.001), and mental HRQoL (r = − .44, p <.001). Multiple regression revealed a significant overall model, (R2 =.28, F(4, 55) = 5.21, p =.001), with fatigue, but not pain, depression, or anxiety, significantly predicting illness intrusiveness (β =.29, p =.036). Results suggest that fatigue may be a primary factor contributing to illness intrusiveness—a determinant of HRQoL—in individuals with SCD. Given the limited sample size, larger confirmatory studies are warranted.
KW - Depression
KW - Fatigue
KW - Pain
KW - Quality of life
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=85149380271&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85149380271&partnerID=8YFLogxK
U2 - 10.1007/s10880-023-09950-8
DO - 10.1007/s10880-023-09950-8
M3 - Article
C2 - 36881316
AN - SCOPUS:85149380271
SN - 1068-9583
VL - 30
SP - 866
EP - 875
JO - Journal of Clinical Psychology in Medical Settings
JF - Journal of Clinical Psychology in Medical Settings
IS - 4
ER -