Illicit drug use and risk for USA300 methicillin-resistant staphylococcus aureus infections with bacteremia

Kristen M. Kreisel, J. Kristie Johnson, O. Colin Stine, Michelle D. Shardell, Eli N. Perencevich, Alan J. Lesse, Fred M. Gordin, Michael W. Climo, Mary Claire Roghmann

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

To assess the association of illicit drug use and USA300 methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, a multicenter study was conducted at 4 Veterans Affairs medical centers during 2004-2008. The study showed that users of illicit drugs were more likely to have USA300 MRSA bacteremia (in contrast to bacteremia caused by other S. aureus strains) than were patients who did not use illicit drugs (adjusted relative risk 3.0; 95% confidence interval 1.9-4.4). The association of illicit drug use with USA300 MRSA bacteremia decreased over time (p = 0.23 for trend). Notably, the proportion of patients with USA300 MRSA bacteremia who did not use illicit drugs increased over time. This finding suggests that this strain has spread from users of illicit drugs to other populations.

Original languageEnglish (US)
Pages (from-to)1419-1427
Number of pages9
JournalEmerging Infectious Diseases
Volume16
Issue number9
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

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