IgM autoagglutinins in warm autoimmune hemolytic anemia: A poor prognostic feature

E. L. McCann, R. S. Shirey, T. S. Kickler, P. M. Ness

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The presence of both complete IgM autoagglutinins and IgG autoantibodies in warm autoimmune hemolytic anemia (AIHA) is an uncommon finding. Over a 6-year period, only 5 of 115 (4.1%) patients with AIHA had IgM and IgG autoantibodies. In 3 of the 5 cases, the complete IgM autoagglutinins reacted up to 30°C and these patients responded well to corticosteroid or other therapies for warm AIHA. The 2 patients who had warm (37°C) reactive IgM autoagglutinins, were refractory to corticosteroids, splenectomy and cytotoxic drugs, and died due to the complications of hemolytic anemia. The data in these 5 cases suggest that the thermal amplitude of the IgM antibody in these unusual AIHA cases may be predictive of refractoriness to therapy and poor clinical outcome.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalActa Haematologica
Issue number2-3
StatePublished - Jan 1 1992


  • Autoimmune hemolytic anemia
  • IgM autoagglutinins

ASJC Scopus subject areas

  • Hematology


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