IgG4-related disease of the aortic valve: A report of two cases and review of the literature

Joseph J. Maleszewski; Henry D. Tazelaar; Heidi M. Horcher; Thomas J. Hinkamp; John V. Conte; James K. Porterfield; Marc K. Halushka

doi:10.1016/j.carpath.2014.08.001

IgG4-related disease of the aortic valve: A report of two cases and review of the literature

Joseph J. Maleszewski, Henry D. Tazelaar, Heidi M. Horcher, Thomas J. Hinkamp, John V. Conte, James K. Porterfield, Marc K. Halushka

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

IgG4-related disease (IgG4-RD) is a relatively recently described disorder that can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are of the aorta, usually the abdominal aorta, rare isolated reports of involvement of the heart proper have been described. Herein, we describe two cases of IgG4-RD involving the aortic valve. Each case was found to be associated with increased levels of IgG4 in the tissue and one case resulted in the subsequent discovery of IgG4-related pancreatitis.

Original language	English (US)
Pages (from-to)	56-59
Number of pages	4
Journal	Cardiovascular Pathology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.carpath.2014.08.001
State	Published - Jan 1 2015

Keywords

Endocarditis
Immunologic
Plasma cells

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.carpath.2014.08.001

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title = "IgG4-related disease of the aortic valve: A report of two cases and review of the literature",

abstract = "IgG4-related disease (IgG4-RD) is a relatively recently described disorder that can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are of the aorta, usually the abdominal aorta, rare isolated reports of involvement of the heart proper have been described. Herein, we describe two cases of IgG4-RD involving the aortic valve. Each case was found to be associated with increased levels of IgG4 in the tissue and one case resulted in the subsequent discovery of IgG4-related pancreatitis.",

keywords = "Endocarditis, Immunologic, Plasma cells",

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AU - Tazelaar, Henry D.

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AU - Hinkamp, Thomas J.

AU - Conte, John V.

AU - Porterfield, James K.

AU - Halushka, Marc K.

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AB - IgG4-related disease (IgG4-RD) is a relatively recently described disorder that can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are of the aorta, usually the abdominal aorta, rare isolated reports of involvement of the heart proper have been described. Herein, we describe two cases of IgG4-RD involving the aortic valve. Each case was found to be associated with increased levels of IgG4 in the tissue and one case resulted in the subsequent discovery of IgG4-related pancreatitis.

KW - Endocarditis

KW - Immunologic

KW - Plasma cells

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IgG4-related disease of the aortic valve: A report of two cases and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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