IgG subclass levels in pediatric patients on chronic peritoneal dialysis

Alicia M. Neu; Barbara W. Case; Howard M. Lederman; Barbara A. Fivush

doi:10.1007/BF00860740

IgG subclass levels in pediatric patients on chronic peritoneal dialysis

Alicia M. Neu, Barbara W. Case, Howard M. Lederman, Barbara A. Fivush

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities of humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and selective absence of IgG2. We measured serum immunoglobulin and IgG subclass levels in 22 pediatric CPD patients followed at our institution; 8 patients had low total IgG; 4 of these had low levels of IgG2 and 3 also had low IgG1, but IgG2 levels were detected in all patients. Thus, many pediatric CPD patients may have low IgG, and some may have low IgG1 and IgG2 as a reflection of low total IgG. However, we did not demonstrate a selective absence of IgG2 in these patients.

Original language	English (US)
Pages (from-to)	186-188
Number of pages	3
Journal	Pediatric Nephrology
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/BF00860740
State	Published - Apr 1 1995

Keywords

IgG2
Immunodeficiency
Immunoglobulins
Peritoneal dialysis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/BF00860740

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title = "IgG subclass levels in pediatric patients on chronic peritoneal dialysis",

abstract = "Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities of humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and selective absence of IgG2. We measured serum immunoglobulin and IgG subclass levels in 22 pediatric CPD patients followed at our institution; 8 patients had low total IgG; 4 of these had low levels of IgG2 and 3 also had low IgG1, but IgG2 levels were detected in all patients. Thus, many pediatric CPD patients may have low IgG, and some may have low IgG1 and IgG2 as a reflection of low total IgG. However, we did not demonstrate a selective absence of IgG2 in these patients.",

keywords = "IgG2, Immunodeficiency, Immunoglobulins, Peritoneal dialysis",

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AU - Neu, Alicia M.

AU - Case, Barbara W.

AU - Lederman, Howard M.

AU - Fivush, Barbara A.

PY - 1995/4/1

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N2 - Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities of humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and selective absence of IgG2. We measured serum immunoglobulin and IgG subclass levels in 22 pediatric CPD patients followed at our institution; 8 patients had low total IgG; 4 of these had low levels of IgG2 and 3 also had low IgG1, but IgG2 levels were detected in all patients. Thus, many pediatric CPD patients may have low IgG, and some may have low IgG1 and IgG2 as a reflection of low total IgG. However, we did not demonstrate a selective absence of IgG2 in these patients.

AB - Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities of humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and selective absence of IgG2. We measured serum immunoglobulin and IgG subclass levels in 22 pediatric CPD patients followed at our institution; 8 patients had low total IgG; 4 of these had low levels of IgG2 and 3 also had low IgG1, but IgG2 levels were detected in all patients. Thus, many pediatric CPD patients may have low IgG, and some may have low IgG1 and IgG2 as a reflection of low total IgG. However, we did not demonstrate a selective absence of IgG2 in these patients.

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KW - Immunodeficiency

KW - Immunoglobulins

KW - Peritoneal dialysis

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IgG subclass levels in pediatric patients on chronic peritoneal dialysis

Abstract

Keywords

ASJC Scopus subject areas

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