IgE-dependent histamine-releasing factors: A brief review

Susan M. MacDonald, Jacqueline M. Langdon, Brian M. Greenlee, Anne Kagey-Sobotka, Lawrence M. Lichtenstein

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A cytokine, termed histamine-releasing factor (HRF) and produced by many cell types, has become the focus of research by many investigators due to its potential importance as a stimulus in chronic inflammation. We are producing and characterizing an HRF which causes IgE-mediated histamine release from human basophils. Following extensive purification procedures, the molecule will be sequenced and synthesized. A functional heterogeneity of IgE molecules was revealed by these studies. We are currently producing IgE antibody in vitro and testing the hypothesis that differential glycosylation is the basis for the heterogeneity. Knowledge of the structures and interactions of these molecules should advance our understanding of allergic and more chronic diseases.

Original languageEnglish (US)
Pages (from-to)144-147
Number of pages4
JournalInternational archives of allergy and immunology
Issue number1-4
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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