IgE-dependent histamine- releasing factor: A unique cytokine

Jacqueline Langdon, Susan M. Macdonald

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Numerous cytokines have been reported to influence basophil histamine re-lease. The IgE-dependent histamine-releasing factor (HRF), interleukin-3 and mononuclear cell chemotactic activating factor (MCAF) are among the direct agonists of basophil histamine release. Kinetic experiments distinguish these three agonists with only HRF paralleling AIgE-induced release. Furthermore, HRF differs from enhancers of release such as IL-3, IL-1 and stem cell factor. Agents which do not cause release include IL-2, IL-4, IL-5, IL-6, G-CSF and ε-binding-protein. Thus, the IgE-dependent HRF appears to be a novel releasing cytokine.

Original languageEnglish (US)
Pages (from-to)316-318
Number of pages3
JournalInternational archives of allergy and immunology
Issue number2-4
StatePublished - Jan 1 1992


  • Direct basophil agonists
  • HRF
  • Heterogeneity of IgE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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