Abstract
Numerous cytokines have been reported to influence basophil histamine re-lease. The IgE-dependent histamine-releasing factor (HRF), interleukin-3 and mononuclear cell chemotactic activating factor (MCAF) are among the direct agonists of basophil histamine release. Kinetic experiments distinguish these three agonists with only HRF paralleling AIgE-induced release. Furthermore, HRF differs from enhancers of release such as IL-3, IL-1 and stem cell factor. Agents which do not cause release include IL-2, IL-4, IL-5, IL-6, G-CSF and ε-binding-protein. Thus, the IgE-dependent HRF appears to be a novel releasing cytokine.
Original language | English (US) |
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Pages (from-to) | 316-318 |
Number of pages | 3 |
Journal | International archives of allergy and immunology |
Volume | 99 |
Issue number | 2-4 |
DOIs | |
State | Published - Jan 1 1992 |
Keywords
- Direct basophil agonists
- HRF
- Heterogeneity of IgE
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology