IgE-dependent histamine- releasing factor: A unique cytokine

Jacqueline Langdon; Susan M. Macdonald

doi:10.1159/000236272

IgE-dependent histamine- releasing factor: A unique cytokine

Jacqueline Langdon, Susan M. Macdonald

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Numerous cytokines have been reported to influence basophil histamine re-lease. The IgE-dependent histamine-releasing factor (HRF), interleukin-3 and mononuclear cell chemotactic activating factor (MCAF) are among the direct agonists of basophil histamine release. Kinetic experiments distinguish these three agonists with only HRF paralleling AIgE-induced release. Furthermore, HRF differs from enhancers of release such as IL-3, IL-1 and stem cell factor. Agents which do not cause release include IL-2, IL-4, IL-5, IL-6, G-CSF and ε-binding-protein. Thus, the IgE-dependent HRF appears to be a novel releasing cytokine.

Original language	English (US)
Pages (from-to)	316-318
Number of pages	3
Journal	International archives of allergy and immunology
Volume	99
Issue number	2-4
DOIs	https://doi.org/10.1159/000236272
State	Published - Jan 1 1992

Keywords

Direct basophil agonists
HRF
Heterogeneity of IgE

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000236272

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title = "IgE-dependent histamine- releasing factor: A unique cytokine",

abstract = "Numerous cytokines have been reported to influence basophil histamine re-lease. The IgE-dependent histamine-releasing factor (HRF), interleukin-3 and mononuclear cell chemotactic activating factor (MCAF) are among the direct agonists of basophil histamine release. Kinetic experiments distinguish these three agonists with only HRF paralleling AIgE-induced release. Furthermore, HRF differs from enhancers of release such as IL-3, IL-1 and stem cell factor. Agents which do not cause release include IL-2, IL-4, IL-5, IL-6, G-CSF and ε-binding-protein. Thus, the IgE-dependent HRF appears to be a novel releasing cytokine.",

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doi = "10.1159/000236272",

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T1 - IgE-dependent histamine- releasing factor

T2 - A unique cytokine

AU - Langdon, Jacqueline

AU - Macdonald, Susan M.

PY - 1992/1/1

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N2 - Numerous cytokines have been reported to influence basophil histamine re-lease. The IgE-dependent histamine-releasing factor (HRF), interleukin-3 and mononuclear cell chemotactic activating factor (MCAF) are among the direct agonists of basophil histamine release. Kinetic experiments distinguish these three agonists with only HRF paralleling AIgE-induced release. Furthermore, HRF differs from enhancers of release such as IL-3, IL-1 and stem cell factor. Agents which do not cause release include IL-2, IL-4, IL-5, IL-6, G-CSF and ε-binding-protein. Thus, the IgE-dependent HRF appears to be a novel releasing cytokine.

AB - Numerous cytokines have been reported to influence basophil histamine re-lease. The IgE-dependent histamine-releasing factor (HRF), interleukin-3 and mononuclear cell chemotactic activating factor (MCAF) are among the direct agonists of basophil histamine release. Kinetic experiments distinguish these three agonists with only HRF paralleling AIgE-induced release. Furthermore, HRF differs from enhancers of release such as IL-3, IL-1 and stem cell factor. Agents which do not cause release include IL-2, IL-4, IL-5, IL-6, G-CSF and ε-binding-protein. Thus, the IgE-dependent HRF appears to be a novel releasing cytokine.

KW - Direct basophil agonists

KW - HRF

KW - Heterogeneity of IgE

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ER -

IgE-dependent histamine- releasing factor: A unique cytokine

Abstract

Keywords

ASJC Scopus subject areas

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