IgE and FcεRI regulation

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


A central feature of allergic reactions is the aggregation of the high-affinity IgE receptor, FcεRI, to initiate a change in the behavior of the cell expressing the receptor. It is now clear that a number of cell types can express this receptor, which broadens the biology that revolves around IgE antibody. It is also quite clear that the presence of monomeric IgE antibody alters the expression of FcεRI. There remains considerable uncertainty about the importance of independent regulation of the FcεRIβ subunit or its splice variant βT, in terms of regulating both expression and function of FcεRI. There is also only primitive understanding of the role of various polymorphisms in the subunit genes on the atopic phenotype. There are, however, many efforts being made to resolve these issues and to discover other factors that regulate expression of this receptor. Of particular interest for understanding the variation in expression in atopy among patients, the role of this receptor on non-mast cell/hasophils will be important to elucidate.

Original languageEnglish (US)
Pages (from-to)73-88
Number of pages16
JournalAnnals of the New York Academy of Sciences
StatePublished - Jan 1 2005


  • Antibody
  • FCεRIβ subunit
  • FcεRI
  • Function
  • Ige
  • Receptor
  • Regulation
  • Role
  • Variant

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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