TY - JOUR
T1 - IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
AU - Ansotegui, Ignacio J.
AU - Melioli, Giovanni
AU - Canonica, Giorgio Walter
AU - Caraballo, Luis
AU - Villa, Elisa
AU - Ebisawa, Motohiro
AU - Passalacqua, Giovanni
AU - Savi, Eleonora
AU - Ebo, Didier
AU - Gómez, R. Maximiliano
AU - Luengo Sánchez, Olga
AU - Oppenheimer, John J.
AU - Jensen-Jarolim, Erika
AU - Fischer, David A.
AU - Haahtela, Tari
AU - Antila, Martti
AU - Bousquet, Jean J.
AU - Cardona, Victoria
AU - Chiang, Wen Chin
AU - Demoly, Pascal M.
AU - DuBuske, Lawrence M.
AU - Ferrer Puga, Marta
AU - Gerth van Wijk, Roy
AU - González Díaz, Sandra Nora
AU - Gonzalez-Estrada, Alexei
AU - Jares, Edgardo
AU - Kalpaklioğlu, Ayse Füsun
AU - Kase Tanno, Luciana
AU - Kowalski, Marek L.
AU - Ledford, Dennis K.
AU - Monge Ortega, Olga Patricia
AU - Morais Almeida, Mário
AU - Pfaar, Oliver
AU - Poulsen, Lars K.
AU - Pawankar, Ruby
AU - Renz, Harald E.
AU - Romano, Antonino G.
AU - Rosário Filho, Nelson A.
AU - Rosenwasser, Lanny
AU - Sánchez Borges, Mario A.
AU - Scala, Enrico
AU - Senna, Gian Enrico
AU - Sisul, Juan Carlos
AU - Tang, Mimi L.K.
AU - Thong, Bernard Yu Hor
AU - Valenta, Rudolf
AU - Wood, Robert A.
AU - Zuberbier, Torsten
N1 - Funding Information:
The authors wish to thank the allergy societies from the membership of the World Allergy Organization who provided critical review of the draft and the WAO Board of Directors for supporting this work.
Publisher Copyright:
© 2019 The Authors
PY - 2020/2
Y1 - 2020/2
N2 - Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.
AB - Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.
KW - Allergy
KW - Diagnostic strategies
KW - IgE
KW - In vitro tests
KW - Skin tests
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U2 - 10.1016/j.waojou.2019.100080
DO - 10.1016/j.waojou.2019.100080
M3 - Article
C2 - 32128023
AN - SCOPUS:85079872551
SN - 1939-4551
VL - 13
JO - World Allergy Organization Journal
JF - World Allergy Organization Journal
IS - 2
M1 - 100080
ER -