TY - JOUR
T1 - Identifying statin-associated autoimmune necrotizing myopathy
AU - Albayda, Jemima
AU - Christopher-Stine, Lisa
PY - 2014
Y1 - 2014
N2 - Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.
AB - Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.
UR - http://www.scopus.com/inward/record.url?scp=84914159469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84914159469&partnerID=8YFLogxK
U2 - 10.3949/ccjm.81a.13158
DO - 10.3949/ccjm.81a.13158
M3 - Review article
C2 - 25452351
AN - SCOPUS:84914159469
SN - 0891-1150
VL - 81
SP - 736
EP - 741
JO - Cleveland Clinic journal of medicine
JF - Cleveland Clinic journal of medicine
IS - 12
ER -