TY - GEN
T1 - Identifying deregulated TF/miRNA negative and double-negative feedback loops in prostate cancer
AU - Afshar, Ali Sobhi
AU - Xu, Joseph
AU - Goutsias, John
PY - 2013
Y1 - 2013
N2 - Transcription factors (TFs) and MicroRNAs (miRNAs) are two important regulators of gene expression in cells. Although a wealth of information is available on how TFs bind their targets and carry out their regulatory roles, this is not true for miRNAs. Recent observations suggest a high level of coordination between transcriptional regulation by TFs and post-transcriptional regulation by miRNAs. Understanding TF/miRNA interactions and their roles in tumor initiation and progression is an important problem that may lead to systemic insights into the molecular biology of cancer and form a basis for the development of new diagnostic tools and therapeutic approaches. In this paper, we propose an integrated approach for identifying two types of TF/miRNA feedback loops deregulated in prostate cancer. Our approach can be used to assign context-dependent biological functions to TF/miRNA interactions and provide a better understanding of miRNA deregulation in cancer.
AB - Transcription factors (TFs) and MicroRNAs (miRNAs) are two important regulators of gene expression in cells. Although a wealth of information is available on how TFs bind their targets and carry out their regulatory roles, this is not true for miRNAs. Recent observations suggest a high level of coordination between transcriptional regulation by TFs and post-transcriptional regulation by miRNAs. Understanding TF/miRNA interactions and their roles in tumor initiation and progression is an important problem that may lead to systemic insights into the molecular biology of cancer and form a basis for the development of new diagnostic tools and therapeutic approaches. In this paper, we propose an integrated approach for identifying two types of TF/miRNA feedback loops deregulated in prostate cancer. Our approach can be used to assign context-dependent biological functions to TF/miRNA interactions and provide a better understanding of miRNA deregulation in cancer.
UR - http://www.scopus.com/inward/record.url?scp=84897674266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897674266&partnerID=8YFLogxK
U2 - 10.1109/GlobalSIP.2013.6736819
DO - 10.1109/GlobalSIP.2013.6736819
M3 - Conference contribution
AN - SCOPUS:84897674266
SN - 9781479902484
T3 - 2013 IEEE Global Conference on Signal and Information Processing, GlobalSIP 2013 - Proceedings
SP - 85
EP - 88
BT - 2013 IEEE Global Conference on Signal and Information Processing, GlobalSIP 2013 - Proceedings
T2 - 2013 1st IEEE Global Conference on Signal and Information Processing, GlobalSIP 2013
Y2 - 3 December 2013 through 5 December 2013
ER -