TY - JOUR
T1 - Identifying changes in scores on the EORTC-QLQ-C30 representing a change in patients’ supportive care needs
AU - Snyder, Claire F.
AU - Blackford, Amanda L.
AU - Sussman, Jonathan
AU - Bainbridge, Daryl
AU - Howell, Doris
AU - Seow, Hsien Y.
AU - Carducci, Michael A.
AU - Wu, Albert W.
N1 - Funding Information:
This analysis was funded by the American Cancer Society (# MRSG-08-011-01-CPPB). The original data collection was supported by the Canadian Health Services Research Foundation, Ontario Ministry of Health and Long-term Care. Dr Snyder and Dr Carducci are members of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (P30 CA 006973).
Publisher Copyright:
© 2014, Springer International Publishing Switzerland.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Purpose: Using health-related quality-of-life measures for patient management requires knowing what changes in scores require clinical attention. We estimated changes on the European Organization for Research and Treatment of Cancer Quality-of-Life-Questionnaire-Core-30 (EORTC-QLQ-C30), representing important changes by comparing to patient-reported changes in supportive care needs.Methods: This secondary analysis used data from 193 newly diagnosed cancer patients (63 % breast, 37 % colorectal; mean age 60 years; 20 % male) from 28 Canadian surgical practices. Participants completed the Supportive Care Needs Survey-Short Form-34 (SCNS-SF34) and EORTC-QLQ-C30 at baseline, 3, and 8 weeks. We calculated mean changes in EORTC-QLQ-C30 scores associated with improvement, worsening, and no change in supportive care needs based on the SCNS-SF34. Mean changes in the EORTC-QLQ-C30 scores associated with the SCNS-SF34 improved and worsened categories were used to estimate clinically important changes, and the ‘no change’ category to estimate insignificant changes.Results: EORTC-QLQ-C30 score changes ranged from 6 to 32 points for patients reporting improved supportive care needs; statistically significant changes were 10–32 points. EORTC-QLQ-C30 score changes ranged from 21-point worsening to 21-point improvement for patients reporting worsening supportive care needs; statistically significant changes were 9–21 points in the hypothesized direction and a 21-point statistically significant change in the opposite direction. EORTC-QLQ-C30 score changes ranged from a 1-point worsening to 16-point improvement for patients reporting stable supportive care needs.Conclusion: These data suggest 10-point EORTC-QLQ-C30 score changes represent changes in supportive care needs. When using the EORTC-QLQ-C30 in clinical practice, scores changing ≥10 points should be highlighted for clinical attention.
AB - Purpose: Using health-related quality-of-life measures for patient management requires knowing what changes in scores require clinical attention. We estimated changes on the European Organization for Research and Treatment of Cancer Quality-of-Life-Questionnaire-Core-30 (EORTC-QLQ-C30), representing important changes by comparing to patient-reported changes in supportive care needs.Methods: This secondary analysis used data from 193 newly diagnosed cancer patients (63 % breast, 37 % colorectal; mean age 60 years; 20 % male) from 28 Canadian surgical practices. Participants completed the Supportive Care Needs Survey-Short Form-34 (SCNS-SF34) and EORTC-QLQ-C30 at baseline, 3, and 8 weeks. We calculated mean changes in EORTC-QLQ-C30 scores associated with improvement, worsening, and no change in supportive care needs based on the SCNS-SF34. Mean changes in the EORTC-QLQ-C30 scores associated with the SCNS-SF34 improved and worsened categories were used to estimate clinically important changes, and the ‘no change’ category to estimate insignificant changes.Results: EORTC-QLQ-C30 score changes ranged from 6 to 32 points for patients reporting improved supportive care needs; statistically significant changes were 10–32 points. EORTC-QLQ-C30 score changes ranged from 21-point worsening to 21-point improvement for patients reporting worsening supportive care needs; statistically significant changes were 9–21 points in the hypothesized direction and a 21-point statistically significant change in the opposite direction. EORTC-QLQ-C30 score changes ranged from a 1-point worsening to 16-point improvement for patients reporting stable supportive care needs.Conclusion: These data suggest 10-point EORTC-QLQ-C30 score changes represent changes in supportive care needs. When using the EORTC-QLQ-C30 in clinical practice, scores changing ≥10 points should be highlighted for clinical attention.
KW - Cancer
KW - Clinical practice
KW - Clinically important differences
KW - EORTC-QLQ-C30
KW - Patient-reported outcomes
KW - Supportive care needs
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U2 - 10.1007/s11136-014-0853-y
DO - 10.1007/s11136-014-0853-y
M3 - Article
C2 - 25398495
AN - SCOPUS:84939945762
SN - 0962-9343
VL - 24
SP - 1207
EP - 1216
JO - Quality of Life Research
JF - Quality of Life Research
IS - 5
ER -