Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases

Xiaoyi Hu; Anthony Addlagatta; Brian W. Matthews; Jun O. Liu

doi:10.1002/anie.200600757

Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases

Xiaoyi Hu, Anthony Addlagatta, Brian W. Matthews, Jun O. Liu

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

High-throughput screening of a library of compounds has led to the identification of a new structural class of human methionine aminopeptidases inhibitors. They inhibited the processing of 14-3-3γ in cells and blocked proliferation of both endothelial cells and transformed cancer cell lines. The picture shows the crystal structure of the complex of one inhibitor (yellow) with the type 1 human methionine aminopeptidase (blue Co^II, red H₂O). (Figure Presented)

Original language	English (US)
Pages (from-to)	3772-3775
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	23
DOIs	https://doi.org/10.1002/anie.200600757
State	Published - Jun 2 2006

Keywords

Cellular effects
Drug design
Enzymes
Inhibitors
Structure elucidation

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200600757

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abstract = "High-throughput screening of a library of compounds has led to the identification of a new structural class of human methionine aminopeptidases inhibitors. They inhibited the processing of 14-3-3γ in cells and blocked proliferation of both endothelial cells and transformed cancer cell lines. The picture shows the crystal structure of the complex of one inhibitor (yellow) with the type 1 human methionine aminopeptidase (blue CoII, red H2O). (Figure Presented)",

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author = "Xiaoyi Hu and Anthony Addlagatta and Matthews, {Brian W.} and Liu, {Jun O.}",

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AU - Hu, Xiaoyi

AU - Addlagatta, Anthony

AU - Matthews, Brian W.

AU - Liu, Jun O.

PY - 2006/6/2

Y1 - 2006/6/2

N2 - High-throughput screening of a library of compounds has led to the identification of a new structural class of human methionine aminopeptidases inhibitors. They inhibited the processing of 14-3-3γ in cells and blocked proliferation of both endothelial cells and transformed cancer cell lines. The picture shows the crystal structure of the complex of one inhibitor (yellow) with the type 1 human methionine aminopeptidase (blue CoII, red H2O). (Figure Presented)

AB - High-throughput screening of a library of compounds has led to the identification of a new structural class of human methionine aminopeptidases inhibitors. They inhibited the processing of 14-3-3γ in cells and blocked proliferation of both endothelial cells and transformed cancer cell lines. The picture shows the crystal structure of the complex of one inhibitor (yellow) with the type 1 human methionine aminopeptidase (blue CoII, red H2O). (Figure Presented)

KW - Cellular effects

KW - Drug design

KW - Enzymes

KW - Inhibitors

KW - Structure elucidation

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Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases

Abstract

Keywords

ASJC Scopus subject areas

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