Identification of new CRF51-01B in Singapore using full genome analysis of three HIV type 1 isolates

Oon Tek Ng; Lindsay M. Eyzaguirre; Jean K. Carr; Kuan Kiat Chew; Li Lin; Arlene Chua; Yee Sin Leo; Andrew D. Redd; Thomas C. Quinn; Oliver Laeyendecker

doi:10.1089/aid.2011.0177

Identification of new CRF51-01B in Singapore using full genome analysis of three HIV type 1 isolates

Oon Tek Ng, Lindsay M. Eyzaguirre, Jean K. Carr, Kuan Kiat Chew, Li Lin, Arlene Chua, Yee Sin Leo, Andrew D. Redd, Thomas C. Quinn, Oliver Laeyendecker

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01-AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01-AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01-AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51-01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

Original language	English (US)
Pages (from-to)	527-530
Number of pages	4
Journal	AIDS research and human retroviruses
Volume	28
Issue number	5
DOIs	https://doi.org/10.1089/aid.2011.0177
State	Published - May 1 2012
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.2011.0177

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title = "Identification of new CRF51-01B in Singapore using full genome analysis of three HIV type 1 isolates",

abstract = "A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01-AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01-AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01-AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51-01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.",

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AU - Ng, Oon Tek

AU - Eyzaguirre, Lindsay M.

AU - Carr, Jean K.

AU - Chew, Kuan Kiat

AU - Lin, Li

AU - Chua, Arlene

AU - Leo, Yee Sin

AU - Redd, Andrew D.

AU - Quinn, Thomas C.

AU - Laeyendecker, Oliver

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AB - A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01-AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01-AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01-AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51-01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

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Identification of new CRF51-01B in Singapore using full genome analysis of three HIV type 1 isolates

Abstract

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