Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease

Koko Ishizuka; Takemi Kimura; Ruriko Igata-Yi; Shoichi Katsuragi; Junichi Takamatsu; Taihei Miyakawa

doi:10.1111/j.1440-1819.1997.tb02375.x

Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease

Koko Ishizuka, Takemi Kimura, Ruriko Igata-Yi, Shoichi Katsuragi, Junichi Takamatsu, Taihei Miyakawa

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar β- amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

Original language	English (US)
Pages (from-to)	135-138
Number of pages	4
Journal	Psychiatry and Clinical Neurosciences
Volume	51
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1819.1997.tb02375.x
State	Published - 1997
Externally published	Yes

Keywords

Alzheimer's disease
Inflammation
Microglias
Monocyte chemoattractant protein-1
Senile plaques

ASJC Scopus subject areas

General Neuroscience
Neurology
Clinical Neurology
Psychiatry and Mental health

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10.1111/j.1440-1819.1997.tb02375.x

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title = "Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease",

abstract = "It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar β- amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.",

keywords = "Alzheimer's disease, Inflammation, Microglias, Monocyte chemoattractant protein-1, Senile plaques",

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doi = "10.1111/j.1440-1819.1997.tb02375.x",

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AU - Ishizuka, Koko

AU - Kimura, Takemi

AU - Igata-Yi, Ruriko

AU - Katsuragi, Shoichi

AU - Takamatsu, Junichi

AU - Miyakawa, Taihei

PY - 1997

Y1 - 1997

N2 - It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar β- amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

AB - It has been shown that human monocytes express monocyte chemoattractant protein-1 (MCP-1), an inflammatory factor, in response to non-fibrillar β- amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1-immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. Monocyte chemoattractant protein-1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP-1-related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

KW - Alzheimer's disease

KW - Inflammation

KW - Microglias

KW - Monocyte chemoattractant protein-1

KW - Senile plaques

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Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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