TY - JOUR
T1 - Identification of human immunodeficiency virus primary isolates resistant to interferon-α and correlation of prevalence to disease progression
AU - Kiinzi, Myriam S.
AU - Farzadegan, Homayoon
AU - Margolick, Joseph B.
AU - Vlahov, David
AU - Pitha, Paula M.
PY - 1995/4
Y1 - 1995/4
N2 - Human immunodeficiency virus (HIV) primary isolates, derived from donors at various stages of HIV infection, were assayed for their sensitivity to interferon (IFN)-α2 in vitro. These isolates displayed a broad range of sensitivity to IFN-a2. The prevalence of IFN-α2 resistance was low in the absence of AIDS but dramatically increased once HIV infection progressed to AIDS. Although there was no linear correlation between the percentage of IFN-α2 inhibition in vitro and the CD4 cell number in vivo or the level of endogenous IFN-α, serum IFN-α levels were higher in donors with AIDS and were associated with low CD4 cell numbers. Thus, circulating IFN-α appeared to either promote resistance or favor survival of IFN-a-resistant variants. IFN-α2 resistance was neither limited to a particular cell tropism nor enhanced by therapy with zidovudine. Sequential analysis indicated that reversion to IFN-α2 sensitivity could occur during the course of infection.
AB - Human immunodeficiency virus (HIV) primary isolates, derived from donors at various stages of HIV infection, were assayed for their sensitivity to interferon (IFN)-α2 in vitro. These isolates displayed a broad range of sensitivity to IFN-a2. The prevalence of IFN-α2 resistance was low in the absence of AIDS but dramatically increased once HIV infection progressed to AIDS. Although there was no linear correlation between the percentage of IFN-α2 inhibition in vitro and the CD4 cell number in vivo or the level of endogenous IFN-α, serum IFN-α levels were higher in donors with AIDS and were associated with low CD4 cell numbers. Thus, circulating IFN-α appeared to either promote resistance or favor survival of IFN-a-resistant variants. IFN-α2 resistance was neither limited to a particular cell tropism nor enhanced by therapy with zidovudine. Sequential analysis indicated that reversion to IFN-α2 sensitivity could occur during the course of infection.
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U2 - 10.1093/infdis/171.4.822
DO - 10.1093/infdis/171.4.822
M3 - Article
C2 - 7706808
AN - SCOPUS:0028921351
SN - 0022-1899
VL - 171
SP - 822
EP - 828
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -