Identification of elf1, a β-spectrin, in early mouse liver development

Lopa Mishra, Tao Cai, Ariel Levine, David Weng, Esteban Mezey, Bibhuti Mishra, John Gearhart

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


β-spectrins play essential roles in cell-cell interactions and in the maintenance of cell polarity. Our aim was to identify β-spectrin genes important for the establishment of hepatocyte polarity and differentiation. Using subtractive screening of cDNA libraries from early embryonic mouse livers (post-coital days 10, 11, and 12), we have isolated elf1 (embryonic liver fodrin 1), a differentially expressed β-spectrin or fodrin (β SpIIΣI). Elf1 encodes a 220-amino acid protein with an NH2 terminal actin- binding domain. In situ hybridization studies demonstrate elf1 expression initially in day 10 embryonic heart tissue, then in day 11-11.5 hepatic tissue. These studies suggest that elf1 may play a role in the emergence of hepatocyte polarity during liver development.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalInternational Journal of Developmental Biology
Issue number2
StatePublished - Mar 1998


  • In situ hybridization
  • Liver development
  • Spectrin

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology


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