Identification of an amplified, highly expressed gene in a human glioma

Kenneth W. Kinzler, Sandra H. Bigner, Darell D. Bigner, Jeffrey M. Trent, Martha L. Law, Stephen J. O'Brien, Albert J. Wong, Bert Vogelstein

Research output: Contribution to journalArticlepeer-review

530 Scopus citations


A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
Issue number4797
StatePublished - 1987

ASJC Scopus subject areas

  • General


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