Identification of an amplified, highly expressed gene in a human glioma

Kenneth W. Kinzler; Sandra H. Bigner; Darell D. Bigner; Jeffrey M. Trent; Martha L. Law; Stephen J. O'Brien; Albert J. Wong; Bert Vogelstein

doi:10.1126/science.3563490

Identification of an amplified, highly expressed gene in a human glioma

Kenneth W. Kinzler, Sandra H. Bigner, Darell D. Bigner, Jeffrey M. Trent, Martha L. Law, Stephen J. O'Brien, Albert J. Wong, Bert Vogelstein

School of Medicine

Research output: Contribution to journal › Article › peer-review

530 Scopus citations

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Original language	English (US)
Pages (from-to)	70-73
Number of pages	4
Journal	Science
Volume	236
Issue number	4797
DOIs	https://doi.org/10.1126/science.3563490
State	Published - 1987

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title = "Identification of an amplified, highly expressed gene in a human glioma",

abstract = "A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.",

author = "Kinzler, {Kenneth W.} and Bigner, {Sandra H.} and Bigner, {Darell D.} and Trent, {Jeffrey M.} and Law, {Martha L.} and O'Brien, {Stephen J.} and Wong, {Albert J.} and Bert Vogelstein",

year = "1987",

doi = "10.1126/science.3563490",

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volume = "236",

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AU - Kinzler, Kenneth W.

AU - Bigner, Sandra H.

AU - Bigner, Darell D.

AU - Trent, Jeffrey M.

AU - Law, Martha L.

AU - O'Brien, Stephen J.

AU - Wong, Albert J.

AU - Vogelstein, Bert

PY - 1987

Y1 - 1987

N2 - A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

AB - A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

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Identification of an amplified, highly expressed gene in a human glioma

Abstract

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