Abstract
By using a panel of HLA-D-defined subtypes of HLA-DR2 HCL with known β chain structural variabilities, we have demonstrated that HLA-DR2, OKT4+ cytotoxic T lymphocyte (CTL) clones specific for measles virus are apparently restricted to a distinct DR β chain. The presence of this DR β molecule correlated precisely with the susceptibility of measles virus-infected HLA-DR2 HCL to lysis by these CTL clones. These studies demonstrate that delineation of HLA-DR2 into various subgroups can have a functional significance that parallels the structural differences within the HLA-D region. These results are discussed in the context of the possible association of HLA class II-restricted, measles virus-specific CTL and multiple sclerosis.
Original language | English (US) |
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Pages (from-to) | 263-268 |
Number of pages | 6 |
Journal | Journal of Experimental Medicine |
Volume | 161 |
Issue number | 1 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology