Identification of a specialized adenylyl cyclase that may mediate odorant detection

Heather A. Bakalyar, Randall R. Reed

Research output: Contribution to journalArticlepeer-review

502 Scopus citations


The mammalian olfactory system may transduce odorant information via a G protein-mediated adenosine 3′,5′-monophosphate (cAMP) cascade. A newly discovered adenylyl cyclase, termed type III, has been cloned, and its expression was localized to olfactory neurons. The type III protein resides in the sensory neuronal cilia, which project into the nasal lumen and are accessible to airborne odorants. The enzymatic activity of the type III adenylyl cyclase appears to differ from nonsensory cyclases. The large difference seen between basal and stimulated activity for the type III enzyme could allow considerable modulation of the intracellular cAMP concentration. This property may represent one mechanism of achieving sensitivity in odorant perception.

Original languageEnglish (US)
Pages (from-to)1403-1406
Number of pages4
Issue number4986
StatePublished - 1990

ASJC Scopus subject areas

  • General


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