Identification of a nuclear protein matrix

Ronald Berezney, Donald S. Coffey

Research output: Contribution to journalArticlepeer-review

767 Scopus citations


The structural framework of the rat liver nucleus has been identified and consists of a nuclear protein matrix. This matrix is 98.4% protein, 0.1% DNA, 1.2% RNA, and 0.5% phospholipid. The nuclear protein matrix is composed primarily of three acidic polypeptide fractions in the molecular weight range of 60-70,000 daltons.

Original languageEnglish (US)
Pages (from-to)1410-1417
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Oct 23 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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