Abstract
HLA-Cw*05 is one of the least polymorphic subgroups of HLA-C; so far only two alleles, namely Cw*0501 and Cw*0502, have been reported. We report here the identification of a third allele, Cw*0503, in a Caucasian individual. Cw*0503 is closely related to Cw*0501 with only six nucleotide substitutions clustering over a fragment of 48 nucleotides at the beginning of exon 4. All these six substitutions at the same positions have been found only in HLA-B*44 alleles, suggesting that Cw*0503 is a result of recombination between Cw*0501 and one of B*44 alleles.
Original language | English (US) |
---|---|
Pages (from-to) | 473-474 |
Number of pages | 2 |
Journal | Tissue Antigens |
Volume | 55 |
Issue number | 5 |
DOIs | |
State | Published - 2000 |
Keywords
- HLA-Cw*0503
- Nucleotide sequencing
- cDNA cloning
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Genetics