Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B

Keyphrases

• Isocitrate Dehydrogenase 1 (IDH1) 100%
• Functional Target 100%
• Marine Natural Products 100%
• NB4 Cells 30%
• 2-oxoglutarate 20%
• Mutant Isocitrate Dehydrogenase 20%
• Zebrafish Model 20%
• Overexpression 10%
• Hematological Malignancies 10%
• Apoptosis 10%
• Antitumor Activity 10%
• Selective Inhibitor 10%
• Knockdown 10%
• Protein Microarray 10%
• Combined Strategy 10%
• Homeostasis 10%
• Antitumor Effect 10%
• Leukemia Cell Lines 10%
• N-acetylcysteine 10%
• Transcriptome 10%
• Isocitrate 10%
• Endoplasmic Reticulum Stress (ER stress) 10%
• Apoptosis Induction 10%
• Cellular Targets 10%
• Phenotype Microarray 10%
• Putative Targets 10%
• Intracellular Reactive Oxygen Species 10%
• Glycosides 10%
• Actinomycetes 10%
• Antitumor Target 10%
• Acute Promyelocytic Leukemia Cells 10%
• Streptomyces Strains 10%
• Bioactive Secondary Metabolites 10%
• Reactive Oxygen Species Generation 10%
• Angucycline 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Natural Product 100%
• Isocitrate Dehydrogenase 1 100%
• 2 Oxoglutaric Acid 20%
• Zebra Fish 20%
• Reactive Oxygen Metabolite 10%
• Antitumor Activity 10%
• Actinobacteria 10%
• Hematologic Malignancy 10%
• Isocitric Acid 10%
• Promyelocytic Leukemia 10%
• Streptomyces 10%
• Protein Microarray 10%
• Glycoside 10%
• N-Acetylcysteine 10%

Biochemistry, Genetics and Molecular Biology

• Isocitrate Dehydrogenase 100%
• Wild Type 20%
• Zebra Fish 20%
• Programmed Cell Death 20%
• Homeostasis 10%
• Myeloid 10%
• Antineoplastic Activity 10%
• Protein Microarray 10%
• Endoplasmic Reticulum Stress 10%
• Transcriptomics 10%
• Secondary Metabolite 10%
• Glycoside 10%
• Streptomyces 10%
• Actinobacteria 10%
• Acetylcysteine 10%