TY - JOUR
T1 - Id proteins in cell growth and tumorigenesis
AU - Sikder, Hashmat A.
AU - Devlin, Meghann K.
AU - Dunlap, Shariff
AU - Ryu, Byungwoo
AU - Alani, Rhoda M.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. The development of knockout and transgenic animal models for many members of the Id gene family has been particularly useful in sorting out the biologic relevance of these genes and their expression during normal development, malignant transformation, and tumor progression. Here we review the current understanding of Id gene function, the biologic consequences of Id gene expression, and the implications for Id gene regulation of cell growth and tumorigenesis.
AB - Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. The development of knockout and transgenic animal models for many members of the Id gene family has been particularly useful in sorting out the biologic relevance of these genes and their expression during normal development, malignant transformation, and tumor progression. Here we review the current understanding of Id gene function, the biologic consequences of Id gene expression, and the implications for Id gene regulation of cell growth and tumorigenesis.
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U2 - 10.1016/S1535-6108(03)00141-7
DO - 10.1016/S1535-6108(03)00141-7
M3 - Article
C2 - 12842081
AN - SCOPUS:0037710310
SN - 1535-6108
VL - 3
SP - 525
EP - 530
JO - Cancer Cell
JF - Cancer Cell
IS - 6
ER -