TY - JOUR
T1 - ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty
AU - The ICFSR Task Force
AU - Rodriguez-Mañas, L.
AU - Araujo de Carvalho, I.
AU - Bhasin, S.
AU - Bischoff-Ferrari, H. A.
AU - Cesari, M.
AU - Evans, W.
AU - Hare, J. M.
AU - Pahor, M.
AU - Parini, A.
AU - Rolland, Y.
AU - Fielding, R. A.
AU - Walston, J.
AU - Vellas, B.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2020/1
Y1 - 2020/1
N2 - Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world — met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.
AB - Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world — met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.
KW - Frailty
KW - biomarkers
KW - consensus
KW - sarcopenia
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U2 - 10.14283/jfa.2019.32
DO - 10.14283/jfa.2019.32
M3 - Article
C2 - 32150207
AN - SCOPUS:85081530627
SN - 2260-1341
VL - 9
SP - 4
EP - 8
JO - The Journal of frailty & aging
JF - The Journal of frailty & aging
IS - 1
ER -