Icebox, A recessive x-linked mutation in drosophila causing low sexual receptivity

Candace Kerr, John Ringo, Harold Dowse, Erik Johnson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The X-linked recessive mutation icebox (ibx; 1-23, 7F1) of Drosophila melanogaster lowers the sexual receptivity of females. The probability of mating with mature wild-type males is reduced in ibx homozygotes, and the frequency of rejection behavior (rate per minute) towards courting males is increased. ibx fails to complement In(1)RA35, which is a lethal allele of Neuroglian (Nrg, which encodes a transmembrane protein found in embryonic tissues including the nervous system) due to a breakpoint in that gene; however, both I(I)B4 and I(I)VAI42, other lethal mutations of Nrg, do complement ibx. 12-h ibx embryos exhibit a normal pattern of staining for the Neuroglian-specific antibody, Mab BP104. Males and females mutant for ibx have normal egg-to-adult survival and appear normal in several general behavioral traits including olfaction, phototaxis, locomotor activity, and heartbeat, ibx males court normally, and are successful in mating. These characteristics suggest that ibx does not cause sensory or motor defects. Ovarian growth and sperm storage are wild-type in ibx/ibx females. Treatment with the JH analog methoprene increases the receptivity of ibx/ibx females.

Original languageEnglish (US)
Pages (from-to)213-229
Number of pages17
JournalJournal of Neurogenetics
Issue number3-4
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics
  • General Neuroscience


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