TY - GEN
T1 - ICA order selection based on consistency
T2 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
AU - Chen, Jiayu
AU - Calhoun, Vince D.
AU - Liu, Jingyu
PY - 2012
Y1 - 2012
N2 - Independent component analysis (ICA), a blind source separation method, has been shown to be a useful approach to identify genetic components representing combined effects from multiple mutations. However, the ICA order selection for genotype data has been a challenge, since a genetic component usually accounts for a small amount of variance of the data, and makes it difficult to distinguish true signals from background. To address this issue, we propose to select ICA order based on consistency and implement three strategies in this study. Simulations demonstrate robust performances of all three strategies where the selected orders lead to optimal results regardless of ICA performances.
AB - Independent component analysis (ICA), a blind source separation method, has been shown to be a useful approach to identify genetic components representing combined effects from multiple mutations. However, the ICA order selection for genotype data has been a challenge, since a genetic component usually accounts for a small amount of variance of the data, and makes it difficult to distinguish true signals from background. To address this issue, we propose to select ICA order based on consistency and implement three strategies in this study. Simulations demonstrate robust performances of all three strategies where the selected orders lead to optimal results regardless of ICA performances.
UR - http://www.scopus.com/inward/record.url?scp=84881056973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881056973&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2012.6345943
DO - 10.1109/EMBC.2012.6345943
M3 - Conference contribution
C2 - 23365904
AN - SCOPUS:84881056973
SN - 9781424441198
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 360
EP - 363
BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Y2 - 28 August 2012 through 1 September 2012
ER -