Hypoxic-Ischemic Encephalopathy in the Term Infant

Ali Fatemi; Mary Ann Wilson; Michael V. Johnston

doi:10.1016/j.clp.2009.07.011

Hypoxic-Ischemic Encephalopathy in the Term Infant

Ali Fatemi, Mary Ann Wilson, Michael V. Johnston

Kennedy Krieger Institute

Research output: Contribution to journal › Review article › peer-review

157 Scopus citations

Abstract

Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.

Original language	English (US)
Pages (from-to)	835-858
Number of pages	24
Journal	Clinics in Perinatology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.clp.2009.07.011
State	Published - Dec 2009

Keywords

Apoptosis
Hypothermia
Hypoxia-ischemia
Neonatal encephalopathy
Oxidative stress

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/j.clp.2009.07.011

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title = "Hypoxic-Ischemic Encephalopathy in the Term Infant",

abstract = "Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.",

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AU - Wilson, Mary Ann

AU - Johnston, Michael V.

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N2 - Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.

AB - Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.

KW - Apoptosis

KW - Hypothermia

KW - Hypoxia-ischemia

KW - Neonatal encephalopathy

KW - Oxidative stress

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JO - Clinics in Perinatology

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ER -

Hypoxic-Ischemic Encephalopathy in the Term Infant

Abstract

Keywords

ASJC Scopus subject areas

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