Abstract
A mechanism that may underlie a form of human kidney failure has been delineated in knockout mice. Activation of the oxygen-regulated transcription factor Hif1 and its target gene Cxcr4 leads to increased cell proliferation that interferes with the function of the glomerulus.
Original language | English (US) |
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Pages (from-to) | 996-997 |
Number of pages | 2 |
Journal | Nature medicine |
Volume | 12 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2006 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology