Hypoxia pathway linked to kidney failure

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

A mechanism that may underlie a form of human kidney failure has been delineated in knockout mice. Activation of the oxygen-regulated transcription factor Hif1 and its target gene Cxcr4 leads to increased cell proliferation that interferes with the function of the glomerulus.

Original languageEnglish (US)
Pages (from-to)996-997
Number of pages2
JournalNature medicine
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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