@inbook{2ccceb0a48a94a1da46a2b8339a9063f,
title = "Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy",
abstract = "Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.",
keywords = "Breast cancer, Chemotherapy, Intratumoral hypoxia, Metabolism, Metastasis, Nanog, Pluripotency factor, Relapse, Self-renewal, Stem cell",
author = "Lisha Xiang and Semenza, {Gregg L.}",
note = "Funding Information: G.L.S. is an American Cancer Society Research Professor and the C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine. Cancer research in his lab is supported by the American Cancer Society, Armstrong Family Foundation, Cindy Rosencrans Foundation, and the Emerson Collective Cancer Research Fund. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jan,
day = "1",
doi = "10.1016/bs.acr.2018.11.001",
language = "English (US)",
isbn = "9780128149942",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
pages = "175--212",
editor = "Civin, {Curt I.} and Kingsbury, {Tami J.} and MinJung Kim and Fisher, {Paul B.}",
booktitle = "Cancer Stem Cells",
}