@article{9ddc5c1c7c5d409b81f6ec9e86ca21c9,
title = "Hypoxia-Inducible Factors and Cancer",
abstract = "Purpose of Review: Hypoxia-inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. Recent Findings: HIFs are increased in many forms of cancer and portend a poor prognosis and response to therapy. Summary: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer.",
keywords = "Cancer, HIF, Hypoxia, Metabolism, Sleep apnea, VEGF",
author = "Jun, {Jonathan C.} and Aman Rathore and Haris Younas and Daniele Gilkes and Polotsky, {Vsevolod Y.}",
note = "Funding Information: Acknowledgements Jonathan C. Jun is supported by the Nutrition Obesity Research Center (NORC) under NIH P30DK072488, American Academy of Sleep Medicine Foundation Junior Faculty Award 106-JF-14, and National Institutes of Health 1K08HL109475. Funding Information: Jonathan C. Jun is supported by the Nutrition Obesity Research Center (NORC) under NIH P30DK072488, American Academy of Sleep Medicine Foundation Junior Faculty Award 106-JF-14, and National Institutes of Health 1K08HL109475. Vsevolod Y. Polotsky is supported by the NIH grants R01 HL128970, R01 HL133100, and P50 ES018176 and by the American Sleep Medicine Foundation grant 133-BS-15. Funding Information: Vsevolod Y. Polotsky is supported by the NIH grants R01 HL128970, R01 HL133100, and P50 ES018176 and by the American Sleep Medicine Foundation grant 133-BS-15. Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",
year = "2017",
month = mar,
day = "1",
doi = "10.1007/s40675-017-0062-7",
language = "English (US)",
volume = "3",
journal = "Current Sleep Medicine Reports",
issn = "2198-6401",
publisher = "Springer International Publishing AG",
number = "1",
}