TY - JOUR
T1 - Hypoxia-inducible factor 1
T2 - Master regulator of O2 homeostasis
AU - Semenza, Gregg L.
PY - 1998/10
Y1 - 1998/10
N2 - Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.
AB - Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.
UR - http://www.scopus.com/inward/record.url?scp=0032190614&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032190614&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(98)80016-6
DO - 10.1016/S0959-437X(98)80016-6
M3 - Article
C2 - 9794818
AN - SCOPUS:0032190614
SN - 0959-437X
VL - 8
SP - 588
EP - 594
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -