Hypoxia-Inducible Factor 1

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to hypoxia by activating the transcription of hundreds of target genes. The expression and activity of HIF-1 are oxygen-regulated, which provides a direct mechanism for transducing changes in cellular oxygenation to changes in gene expression. HIF-1 regulates the expression of genes encoding proteins that play key roles in mediating the switch to glycolytic metabolism, the induction of angiogenesis, and the production of survival factors that block ischemia-induced apoptosis. Induction of HIF-1 activity or administration of survival factors encoded by HIF-1 target genes may be of therapeutic benefit in patients with acute stroke.

Original languageEnglish (US)
Title of host publicationContemporary Clinical Neuroscience
PublisherSpringer Nature
Pages277-288
Number of pages12
DOIs
StatePublished - 2009

Publication series

NameContemporary Clinical Neuroscience
ISSN (Print)2627-535X
ISSN (Electronic)2627-5341

Keywords

  • angiogenesis
  • carotid body
  • erythropoietin
  • glycolysis
  • hypoxia
  • ischemia
  • oxygen
  • preconditioning
  • stroke

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Behavioral Neuroscience

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