TY - JOUR
T1 - Hypoxia and the extracellular matrix
T2 - Drivers of tumour metastasis
AU - Gilkes, Daniele M.
AU - Semenza, Gregg L.
AU - Wirtz, Denis
N1 - Funding Information:
D.M.G. is supported by funding from the National Cancer Institute (NCI) (K99CA181352) and is a Susan G. Komen postdoctoral fellow. Cancer research in the Wirtz laboratory is supported by the US National Insititutes of Health (grants U54-CA143868 and R01-CA174388). Cancer Research in the Semenza laboratory is supported by the American Cancer Society, NCI grant U54-CA143868, the Department of Defense Breast Cancer Research Program and the Johns Hopkins Institute for Cell Engineering. G.L.S. is the C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine, USA, and an American Cancer Society Research Professor. D.W. is the T.H. Smoot Professor and Vice Provost for Research at Johns Hopkins University.
PY - 2014/6
Y1 - 2014/6
N2 - Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular matrix (ECM) might have crucial roles in metastasis. During tumour evolution, changes in the composition and the overall content of the ECM reflect both its biophysical and biological properties and these strongly influence tumour and stromal cell properties, such as proliferation and motility. Originally thought of as independent contributors to metastatic spread, recent studies have established a direct link between hypoxia and the composition and the organization of the ECM, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
AB - Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular matrix (ECM) might have crucial roles in metastasis. During tumour evolution, changes in the composition and the overall content of the ECM reflect both its biophysical and biological properties and these strongly influence tumour and stromal cell properties, such as proliferation and motility. Originally thought of as independent contributors to metastatic spread, recent studies have established a direct link between hypoxia and the composition and the organization of the ECM, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
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U2 - 10.1038/nrc3726
DO - 10.1038/nrc3726
M3 - Review article
C2 - 24827502
AN - SCOPUS:84901594345
SN - 1474-175X
VL - 14
SP - 430
EP - 439
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 6
ER -