Hypoxia and Hypoxia-Inducible Factors in Lymphedema

Xinguo Jiang, Wen Tian, Dongeon Kim, Alexander S. McQuiston, Ryan Vinh, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls

Research output: Contribution to journalReview articlepeer-review

Abstract

Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments.

Original languageEnglish (US)
Article number851057
JournalFrontiers in Pharmacology
Volume13
DOIs
StatePublished - Mar 28 2022

Keywords

  • HIF
  • hypoxia
  • inflammation
  • lymphangiogensis
  • lymphedema

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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