Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Francis J. Mussai; Lea C. Cunningham; Geoffrey Rezvani; Constantine A. Stratakis; James C. Reynolds; Galina Nesterova; Robert M. Henshaw; Jason E. Levine; Lee J. Helman; Diane C. Arthur; Su Young Kim

doi:10.1097/MPH.0b013e318168f072

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Francis J. Mussai, Lea C. Cunningham, Geoffrey Rezvani, Constantine A. Stratakis, James C. Reynolds, Galina Nesterova, Robert M. Henshaw, Jason E. Levine, Lee J. Helman, Diane C. Arthur, Su Young Kim

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.

Original language	English (US)
Pages (from-to)	612-617
Number of pages	6
Journal	Journal of Pediatric Hematology/Oncology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1097/MPH.0b013e318168f072
State	Published - Aug 2008
Externally published	Yes

Keywords

22q11.2 deletion syndrome
Hypocalcemia
Osteosarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1097/MPH.0b013e318168f072

Cite this

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title = "Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome",

abstract = "Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.",

keywords = "22q11.2 deletion syndrome, Hypocalcemia, Osteosarcoma",

author = "Mussai, {Francis J.} and Cunningham, {Lea C.} and Geoffrey Rezvani and Stratakis, {Constantine A.} and Reynolds, {James C.} and Galina Nesterova and Henshaw, {Robert M.} and Levine, {Jason E.} and Helman, {Lee J.} and Arthur, {Diane C.} and Kim, {Su Young}",

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doi = "10.1097/MPH.0b013e318168f072",

language = "English (US)",

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T1 - Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

AU - Mussai, Francis J.

AU - Cunningham, Lea C.

AU - Rezvani, Geoffrey

AU - Stratakis, Constantine A.

AU - Reynolds, James C.

AU - Nesterova, Galina

AU - Henshaw, Robert M.

AU - Levine, Jason E.

AU - Helman, Lee J.

AU - Arthur, Diane C.

AU - Kim, Su Young

PY - 2008/8

Y1 - 2008/8

N2 - Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.

AB - Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome.

KW - 22q11.2 deletion syndrome

KW - Hypocalcemia

KW - Osteosarcoma

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Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Abstract

Keywords

ASJC Scopus subject areas

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