Hypertrophy of alveolar wall cells secondary to an air pollutant

Russell P. Sherwin, Russell P. Sherwin, Joseph B. Margolick, Stanley P. Azen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


When guinea pigs were exposed to 2 ppm nitrogen dioxide continously for 7, 14, and 21 days, a significant increase was found in the average area per alveolar wall cell (P < .025). The duration of the experiment was also significant (P <.05). The method as used, based on an image analyzer quantitation of 9,824 lactate dehydrogenase- positive alveolar wall cells, can contribute to the basic understanding of the type 2 pneumocyte and potentially to the establishment of air quality standards.

Original languageEnglish (US)
Pages (from-to)297-299
Number of pages3
JournalArchives of Environmental Health
Issue number6
StatePublished - Jun 1973
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • General Environmental Science
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Hypertrophy of alveolar wall cells secondary to an air pollutant'. Together they form a unique fingerprint.

Cite this