Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes.

C. Kilewo; U. C. Natchu; A. Young; D. Donnell; E. Brown; J. S. Read; U. Sharma; B. H. Chi; R. Goldenberg; I. Hoffman; T. E. Taha; W. W. Fawzi

Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes.

C. Kilewo, U. C. Natchu, A. Young, D. Donnell, E. Brown, J. S. Read, U. Sharma, B. H. Chi, R. Goldenberg, I. Hoffman, T. E. Taha, W. W. Fawzi

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.

Original language	English (US)
Pages (from-to)	25-36
Number of pages	12
Journal	African Journal of Reproductive Health
Volume	13
Issue number	4
State	Published - Dec 2009
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Public Health, Environmental and Occupational Health

Cite this

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title = "Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes.",

abstract = "This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.",

author = "C. Kilewo and Natchu, {U. C.} and A. Young and D. Donnell and E. Brown and Read, {J. S.} and U. Sharma and Chi, {B. H.} and R. Goldenberg and I. Hoffman and Taha, {T. E.} and Fawzi, {W. W.}",

year = "2009",

month = dec,

language = "English (US)",

volume = "13",

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journal = "African journal of reproductive health",

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AU - Kilewo, C.

AU - Natchu, U. C.

AU - Young, A.

AU - Donnell, D.

AU - Brown, E.

AU - Read, J. S.

AU - Sharma, U.

AU - Chi, B. H.

AU - Goldenberg, R.

AU - Hoffman, I.

AU - Taha, T. E.

AU - Fawzi, W. W.

PY - 2009/12

Y1 - 2009/12

N2 - This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.

AB - This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.

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ER -

Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes.

Abstract

ASJC Scopus subject areas

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