Hyperorality in Frontotemporal Dementia: Cognitive and Psychiatric Symptom Profiles in Early-Stage Disease

Christopher B. Morrow; Grace Anna S. Chaney; Daniel Capuzzi; Arnold Bakker; Chiadi U. Onyike; Vidyulata Kamath

doi:10.3233/JAD-220443

Hyperorality in Frontotemporal Dementia: Cognitive and Psychiatric Symptom Profiles in Early-Stage Disease

Christopher B. Morrow, Grace Anna S. Chaney, Daniel Capuzzi, Arnold Bakker, Chiadi U. Onyike, Vidyulata Kamath

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Hyperorality is a distinctive feature of the behavioral variant of frontotemporal dementia (bvFTD), but little is known about its significance in early-stage disease. This study examined the cognitive and psychiatric symptom profiles associated with hyperorality, using data from subjects with early-stage bvFTD enrolled in Alzheimer's Disease Research Centers. We found that hyperorality was not associated with cognitive performance, but was associated with psychosis, elation, and disinhibition. Hyperorality may share neurobiology with a subset of early psychiatric symptoms, a finding which could help identify targets for future treatment.

Original language	English (US)
Pages (from-to)	1203-1209
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	89
Issue number	4
DOIs	https://doi.org/10.3233/JAD-220443
State	Published - 2022

Keywords

Cognition
early-stage dementia
frontotemporal dementia
hyperorality
neuropsychiatric symptoms
neuropsychological profile

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health
Clinical Psychology
General Neuroscience

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10.3233/JAD-220443

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abstract = "Hyperorality is a distinctive feature of the behavioral variant of frontotemporal dementia (bvFTD), but little is known about its significance in early-stage disease. This study examined the cognitive and psychiatric symptom profiles associated with hyperorality, using data from subjects with early-stage bvFTD enrolled in Alzheimer's Disease Research Centers. We found that hyperorality was not associated with cognitive performance, but was associated with psychosis, elation, and disinhibition. Hyperorality may share neurobiology with a subset of early psychiatric symptoms, a finding which could help identify targets for future treatment.",

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AB - Hyperorality is a distinctive feature of the behavioral variant of frontotemporal dementia (bvFTD), but little is known about its significance in early-stage disease. This study examined the cognitive and psychiatric symptom profiles associated with hyperorality, using data from subjects with early-stage bvFTD enrolled in Alzheimer's Disease Research Centers. We found that hyperorality was not associated with cognitive performance, but was associated with psychosis, elation, and disinhibition. Hyperorality may share neurobiology with a subset of early psychiatric symptoms, a finding which could help identify targets for future treatment.

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Hyperorality in Frontotemporal Dementia: Cognitive and Psychiatric Symptom Profiles in Early-Stage Disease

Abstract

Keywords

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