@article{9e594eacc25f42799e12b285c38d5c98,
title = "Hypermutation In Pancreatic Cancer",
abstract = "Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair were enriched in those with the highest mutation burdens. Mismatch repair deficiency was identified in 1% of tumors harboring different mechanisms of somatic inactivation of MLH1 and MSH2. Defining mutation load in individual pancreatic cancers and the optimal assay for patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.",
keywords = "Cancer Genetics, Pancreatic Adenocarcinoma, Sequencing, Somatic Rearrangement",
author = "{Australian Pancreatic Cancer Genome Initiative} and Humphris, {Jeremy L.} and Patch, {Ann Marie} and Katia Nones and Bailey, {Peter J.} and Johns, {Amber L.} and Skye McKay and Chang, {David K.} and Miller, {David K.} and Marina Pajic and Kassahn, {Karin S.} and Quinn, {Michael C.J.} and Bruxner, {Timothy J.C.} and Christ, {Angelika N.} and Ivon Harliwong and Senel Idrisoglu and Suzanne Manning and Craig Nourse and Ehsan Nourbakhsh and Andrew Stone and Wilson, {Peter J.} and Matthew Anderson and Fink, {J. Lynn} and Oliver Holmes and Stephen Kazakoff and Conrad Leonard and Felicity Newell and Nick Waddell and Scott Wood and Mead, {Ronald S.} and Qinying Xu and Jianmin Wu and Mark Pinese and Cowley, {Mark J.} and Jones, {Marc D.} and Nagrial, {Adnan M.} and Chin, {Venessa T.} and Chantrill, {Lorraine A.} and Amanda Mawson and Angela Chou and Scarlett, {Christopher J.} and Pinho, {Andreia V.} and Ilse Rooman and Marc Giry-Laterriere and Samra, {Jaswinder S.} and Kench, {James G.} and Hruban, {Ralph H.} and Iacobuzio-Donahue, {Christine A.} and Schulick, {Richard D.} and Wolfgang, {Christopher L.} and Eshleman, {James R.}",
note = "Publisher Copyright: {\textcopyright} 2017 AGA Institute",
year = "2017",
month = jan,
day = "1",
doi = "10.1053/j.gastro.2016.09.060",
language = "English (US)",
volume = "152",
pages = "68--74.e2",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders",
number = "1",
}