Hypericum perforatum extracts as potential antidepressants

Benedetto Vitiello

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Extracts of Hypericum perforatum have been used in the treatment of mild to moderate depression for many years in Europe. More recently, these extracts have become available in the USA as dietary supplements and have been popularly used to improve mood. In support of this practice, data from several controlled clinical studies suggest that Hypericum perforatum is better than placebo and as effective as established antidepressant drugs. These data have, however, several limitations that should temper our enthusiasm and argue for more research before accepting Hypericum perforatum extracts into our pharmacopoeia of established antidepressants. Extant data on the possible effects of Hypericum perforatum extracts in depression are here critically reviewed and plans for further research presented.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Issue number5
StatePublished - May 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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