TY - JOUR
T1 - Hyperglycemia is associated with relatively lower lean body mass in older adults
AU - Kalyani, Rita Rastogi
AU - Tra, Y.
AU - Egan, J. M.
AU - Ferrucci, L.
AU - Brancati, F.
N1 - Publisher Copyright:
© 2014, Serdi and Springer-Verlag France.
PY - 2014/11/18
Y1 - 2014/11/18
N2 - Background/Objectives: Older adults with known diabetes are vulnerable to accelerated loss of lean body mass. However, the relationship of hyperglycemia per se with lean body mass is not fully understood. We sought to examine the independent relationship of hyperglycemia with relative lean body mass in older persons without a reported history of diabetes.Design: Cross-sectional nationally representative survey.Setting: United States.Participants: We studied U.S. adults >50 years without known diabetes (n=5434) in the National Health and Nutrition Examination Survey (1999–2004).Measurements: In linear regression models, we studied the relationship of measured HbA1c (<5.0%, 5.0–5.4%, 5.5–5.9%, 6.0–6.4%, ≥6.5%) with percent lean body mass, measured by dual-energy x-ray absorptiometry, after accounting for potential confounders.Results: Among older U.S. men and women, progressively higher HbA1c was associated with relatively lower total, appendicular, and trunk percent lean mass, independent of demographics and height (all p<0.05). Accounting for physical activity, C-reactive protein, and diabetes-related comorbidities (heart disease, peripheral arterial disease, arthritis, neuropathy, hip fracture, amputation, cancer, pulmonary disease), undiagnosed diabetes (i.e. HbA1c ≥6.5%) versus reference (<5.0%) in both men and women was associated with lower total (−3.5±0.8% and −2.9±0.8%), appendicular (−1.8±0.5% and −1.2±0.4%), and trunk percent lean mass (−1.2±0.4% and −1.3±0.5%), respectively (all p<0.05). Persons at increased risk for diabetes (i.e. HbA1c 6.0–6.4%) also had significant decrements at these sites versus reference.Conclusions: Hyperglycemia is associated with relatively lower lean mass in a nationally representative population of older adults without history of diabetes. Future longitudinal studies are needed to investigate the relationship of hyperglycemia with the accelerated decline of skeletal muscle mass in older persons.
AB - Background/Objectives: Older adults with known diabetes are vulnerable to accelerated loss of lean body mass. However, the relationship of hyperglycemia per se with lean body mass is not fully understood. We sought to examine the independent relationship of hyperglycemia with relative lean body mass in older persons without a reported history of diabetes.Design: Cross-sectional nationally representative survey.Setting: United States.Participants: We studied U.S. adults >50 years without known diabetes (n=5434) in the National Health and Nutrition Examination Survey (1999–2004).Measurements: In linear regression models, we studied the relationship of measured HbA1c (<5.0%, 5.0–5.4%, 5.5–5.9%, 6.0–6.4%, ≥6.5%) with percent lean body mass, measured by dual-energy x-ray absorptiometry, after accounting for potential confounders.Results: Among older U.S. men and women, progressively higher HbA1c was associated with relatively lower total, appendicular, and trunk percent lean mass, independent of demographics and height (all p<0.05). Accounting for physical activity, C-reactive protein, and diabetes-related comorbidities (heart disease, peripheral arterial disease, arthritis, neuropathy, hip fracture, amputation, cancer, pulmonary disease), undiagnosed diabetes (i.e. HbA1c ≥6.5%) versus reference (<5.0%) in both men and women was associated with lower total (−3.5±0.8% and −2.9±0.8%), appendicular (−1.8±0.5% and −1.2±0.4%), and trunk percent lean mass (−1.2±0.4% and −1.3±0.5%), respectively (all p<0.05). Persons at increased risk for diabetes (i.e. HbA1c 6.0–6.4%) also had significant decrements at these sites versus reference.Conclusions: Hyperglycemia is associated with relatively lower lean mass in a nationally representative population of older adults without history of diabetes. Future longitudinal studies are needed to investigate the relationship of hyperglycemia with the accelerated decline of skeletal muscle mass in older persons.
KW - Hyperglycemia
KW - diabetes
KW - elderly
KW - muscle function
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U2 - 10.1007/s12603-014-0538-9
DO - 10.1007/s12603-014-0538-9
M3 - Article
C2 - 25286453
AN - SCOPUS:84911379741
SN - 1279-7707
VL - 18
SP - 737
EP - 743
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
IS - 8
ER -