Hyperfine artifacts in electron paramagnetic resonance imaging

Periannan Kuppusamy, Jay L. Zweier

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Low-molecular weight nitroxide labels (nitroxides) are commonly used as probes in electron paramagnetic resonance (EPR) spectroscopy. The nitroxides exhibit multiple lines in their EPR spectrum due to hyperfine coupling of the unpaired electron with the nitrogen nucleus. In EPR imaging, these hyperfine lines cause either hyperfine-based limitations in the maximum obtainable image resolution or hyperfine-based artifacts in the reconstructed image. In this article we discuss the effect of hyperfine artifacts on the quality of the image and report the application of a numerical method based on forward-subtraction principles for removing hyperfine artifacts in the measured projections. We demonstrate using computer simulations and imaging phantoms that marked enhancement in image quality and resolution can be obtained by removing the hyperfine-imposed limit on the gradient magnitude and performing post-acquisition corrections for removing hyperfine artifacts in the image.

Original languageEnglish (US)
Pages (from-to)593-604
Number of pages12
JournalResearch on Chemical Intermediates
Issue number6
StatePublished - Jun 1996

ASJC Scopus subject areas

  • General Chemistry


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