Hyperferritinemia in Malignant Histiocytosis and Virus-Associated Hemophagocytic Syndrome

Noriko Esumi, Satoshi Ikushima, Shinjiro Todo, Shinsaku Imashuku

Research output: Contribution to journalLetterpeer-review

46 Scopus citations


To the Editor: Serum ferritin levels are increased in many disease conditions, including iron overload, hepatic inflammation or damage, and malignant disorders, such as Hodgkin's disease,1 neuroblastoma,2 leukemia,3 and other cancers.4 In 1984, Andreesen et al.5 demonstrated that intracellular levels of ferritin increased about 100-fold during the maturation of monocytes into macrophages in vitro. Worwood et al.6 reported that cultured mononuclear cells that were maintained in iron-containing medium or were in the process of phagocytizing red cells rapidly accumulated ferritin, suggesting that phagocytic cells may be an important source of serum ferritin. There are, however, few clinical data describing serum…, No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)346-347
Number of pages2
JournalNew England Journal of Medicine
Issue number6
StatePublished - Feb 5 1987
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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