Hydroxylation of HIF-1: Oxygen sensing at the molecular level

Research output: Contribution to journalReview articlepeer-review

688 Scopus citations


The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
Issue number4
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Physiology


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