Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding

Waka Nakanishi; Kazuya Kikuchi; Takanari Inoue; Kenzo Hirose; Masamitsu Iino; Tetsuo Nagano

doi:10.1016/S0960-894X(02)00044-6

Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding

Waka Nakanishi, Kazuya Kikuchi, Takanari Inoue, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Inositol 1,4,5-trisphosphate (IP₃) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP₃ for strong binding to the IP₃ receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.

Original language	English (US)
Pages (from-to)	911-913
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(02)00044-6
State	Published - Mar 25 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(02)00044-6

Cite this

@article{643144096cf645afacc23370e5c6def3,

title = "Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding",

abstract = "Inositol 1,4,5-trisphosphate (IP3) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP3 for strong binding to the IP3 receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.",

author = "Waka Nakanishi and Kazuya Kikuchi and Takanari Inoue and Kenzo Hirose and Masamitsu Iino and Tetsuo Nagano",

note = "Funding Information: We thank Dr. M. Tanabe for her technical assistance and Drs. K. Mikoshiba and T. Furuichi for their kind gift of cDNA of human IP 3 receptor type 1. This work was supported in part by the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2002",

month = mar,

day = "25",

doi = "10.1016/S0960-894X(02)00044-6",

language = "English (US)",

volume = "12",

pages = "911--913",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding

AU - Nakanishi, Waka

AU - Kikuchi, Kazuya

AU - Inoue, Takanari

AU - Hirose, Kenzo

AU - Iino, Masamitsu

AU - Nagano, Tetsuo

N1 - Funding Information: We thank Dr. M. Tanabe for her technical assistance and Drs. K. Mikoshiba and T. Furuichi for their kind gift of cDNA of human IP 3 receptor type 1. This work was supported in part by the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2002/3/25

Y1 - 2002/3/25

N2 - Inositol 1,4,5-trisphosphate (IP3) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP3 for strong binding to the IP3 receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.

AB - Inositol 1,4,5-trisphosphate (IP3) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP3 for strong binding to the IP3 receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.

UR - http://www.scopus.com/inward/record.url?scp=0037170818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037170818&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(02)00044-6

DO - 10.1016/S0960-894X(02)00044-6

M3 - Article

C2 - 11958992

AN - SCOPUS:0037170818

SN - 0960-894X

VL - 12

SP - 911

EP - 913

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this